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Pablo Serrano Fernández

Contact
Contact
Address:   International Hereditary
                  Cancer Center (IHCC)
                  Polabska 4
                  PL-70115 Szczecin
                  Poland

e-mail:    ihcc at pabloserrano dot eu

Tel.:        +48 91 4661532
Fax:        +48 91 4661533

Short curriculum overview
Curriculum
  • Born in Madrid, Spain, 1973 and soon afterwards
  • Student at the German School of Madrid, till my graduation in 1991. In the same year I started studying Biology until I got my 
  • Master of Sciences in Biology (1996) at the Universidad Autónoma de Madrid. Meanwhile I was also busy with a parallel study. I finished it some years later with the degree of
  • Ph.D. in Biology (2003) at the Universidad de Alcalá , Spain. The dissertation discussed the relevance of some Frequency Modulations  as social signals involved in the electric communication among South American Knifefish. The work has to be adscribed equally to the areas of ethology and bioinformatics. The research was carried out mainly at the Zoology Institute of the Regensburg University, Germany. Click here to access the PhD Thesis (PDF Format). However, my interest field is still very broad and therefore I started
  • Computer Sciences studies (2001) at the aforementioned Universidad Nacional de Educación a Distancia.

Didactics

Recent Research Activity

Genetics - Proteomics
In 2003 my work at the Proteome Center Rostock focused on the relevance of some chromosomal regions called quantitative trait loci (QTLs) for the onset and development of different autoimmune diseases.

In collaboration with Dr. Steffen Möller, Dr. Saleh Ibrahim, Gertrud Fischer and Claudia Voigt, I developed some bioinformatic tools suited for a reliable conversion between different genetic mapping systems [CARTOGRAPHER].

This software was also integrated in a further bioinformatic tool that combines QTL information with Gene Expression Profiling as an extension of the EnsEMBL features [EXPRESSIONVIEW].

I also collected data for the construction of a broad database on Multiple Sclerosis and its animal model (Experimental Autoimmune Encephalomyelitis), as well as Rheumatoid Arthritis and its animal model (Collagen Induced Arthritis) [QTLGROUP].

Furthermore, we developed a genome-based software tool to generate new information when comparing QTLs relevant for the same disease in different animals (intergenomics). This tool allowed us not only to determine the most interesting candidate genes within the different QTLs, but also to examine the validity of the animal experimentally induced disease as a relevant model for the human disease[QTLVIEW]

During 2004 I worked for the Steinbeis Technology Transfer Center (STZ) in the context of a cooperation between the Institute of Neurology and the Institute of Immunology of the Medical Faculty of the University Rostock. The project made use of transcriptomics technology in large-scale therapy monitoring of multiple sclerosis patients. The future projection of the study should assess the applicability of this technology to detect patient groups differentiated a priori as responders or non-responders for certain drug therapies.

Currently I am employed at the International Hereditary Cancer Center of the Pomeranian Academy of Medicine (Szczecin, Poland) in the context of the VI. European Research Frame to carry out genetic linkage and association studies in Polish consecutive cases and Polish families with a high incidence of different types of cancer. I also analyze interactions of low and moderate risk markers turning into high-risk genetic combinations. The project is an international cooperation between our academy of medicine and the Department of Medical Genetics of the University of Helsinki (Finland), the Department of Genetics of the University of Lyon (France) and the Department of Functional Genome Research of the Ernst Arndt Moritz University of Greifswald (Germany) and a number of local cooperation partners in Poland.

Publication list

Publications
  • Morris MR, Hughes DJ, Tian YM, Ricketts CJ, Lau KW, Gentle D, Shuib S, Serrano-Fernandez P, Lubinski J, Wiesener MS, Pugh CW, Latif F, Ratcliffe PJ, Maher ER. Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma. Anticancer Res. 2009; 29(11):4337-43.[Abstract]

  • Dymerska D, Serrano-Fernandez P, Suchy J, Plawski A, Slomski R, Kaklewski K, Scott RJ, Gronwald J, Kladny J, Byrski T, Huzarski T, Lubinski J, Kurzawski G. Combined iPLEX and TaqMan assays to screen for 45 common mutations in Lynch syndrome and FAP patients. J Mol Diagn. 2010; 12(1):82-90. [Abstract]

  • Serrano-Fernandez P, Goertsches R, Koczan D, Fiedler H, Moeller M, Thiesen HJ, Zettl UK. Time-course transcriptomics of IFNB-1b treatment in MS patients. Autoimmunity 2009 [Epub ahead of print] [Abstract].

  • Gapska P, Scott RJ, Serrano-Fernandez P, Mirecka A, Rassoud I, Górski B, Cybulski C, Huzarski T, Byrski T, Nagay L, Maleszka R, Sulikowski M, Lubinski J, Debniak T. Vitamin D receptor variants and the malignant melanoma risk: a population-based study. Cancer Epidemiol. 2009; 33(2):103-7.[Abstract]

  • Jaworowska E, Tarnowska C, Lubinski J, Serrano-Fernández P, Huzarski T, Górski B, Masojc B, Jakubiszyn J, Korytowska A, Kram A, Rabczynski J, Lubinski J. Clinical Characteristics of Laryngeal Cancer in BRCA-1 Mutation Carriers. Anticancer Res. 2009 Jul;29(7):2703-5.[Abstract]

  • Serrano-Fernández P, Debniak T, Gorski B, Bogdanova N, Doerk T, Cybulski C, Huzarski T, Byrski T, Gronwald J, Wokolorczyk D, Narod SA, Lubinski J. Synergistic interaction of variants in CHEK2 and BRCA2 on breast cancer risk. Breast Cancer Res Treat. 2009; 117(1):161-5. [Abstract]

  • Cybulski C, Górski B, Huzarski T, Byrski T, Gronwald J, Debniak T, Wokolorczyk D, Jakubowska A, Serrano-Fernández P, Dork T, Narod SA, Lubinski J. The effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other deleterious CHEK2 or BRCA1 mutations. J Med Genet. 2009 46(2):132-5.[Abstract]

  • Gapska P, Scott RJ, Serrano-Fernandez P, Huzarski T, Byrski T, Kladny J, Gronwald J, Gorski B, Cybulski C, Lubinski J, Debniak T. Vitamin D receptor variants and breast cancer risk in the Polish population. Breast Cancer Res Treat. 2009; 115(3):629-33.[Abstract]

  • Lubinski J, Korzen M, Gorski B, Cybulski C, Debniak T, Jakubowska A, Jaworska K, Wokolorczyk D, Medrek K, Matyjasik J, Huzarski T, Byrski T, Gronwald J, Masojc B, Lener M, Szymanska A, Szymanska-Pasternak J, Serrano-Fernandez P, Piegat A, Ucinski R, Domagala P, Domagala W, Chosia M, Kladny J, Górecka B, Narod S, Scott R. Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. Breast Cancer Res Treat. 2009; 114(1):121-6.[Abstract]

  • Cybulski C, Masojc B, Oszutowska D, Jaworowska E, Grodzki T, Waloszczyk P, Serwatowski P, Pankowski J, Huzarski T, Byrski T, Górski B, Jakubowska A, Debniak T, Wokolorczyk D, Gronwald J, Tarnowska C, Serrano-Fernandez P, Lubinski J, Narod SA. Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. Carcinogenesis. 2008 Apr;29(4):762-5.[Abstract]

  • Jaworowska E, Serrano-Fernandez P, Tarnowska C, Lubinski J, Brzosko M, Flicinski J, Masojc B, Matyjasik J, Scott RJ, Narod SA, Lubinski J. Familial association of laryngeal, lung, stomach and early-onset breast cancer. Breast Cancer Res Treat. 2008; 112(2):359-61.[Abstract]

  • Lubinski J, Korzen M, Gorski B, Cybulski C, Debniak T, Jakubowska A, Medrek K, Matyjasik J, Huzarski T, Byrski T, Gronwald J, Masojc B, Lener M, Szymanska A, Szymanska-Pasternak J, Serrano-Fernandez P, Wokolorczyk D, Piegat A, Ucinski M, Domagala P, Kladny J, Gorecka B, Scott R, Narod S. Breast cancer susceptibility genes. J BUON. 2007; 12(1):S23-9. [Abstract]

  • Debniak T, Scott RJ, Górski B, Cybulski C, van de Wetering T, Serrano-Fernandez P, Huzarski T, Byrski T, Nagay L, Debniak B, Kowalska E, Jakubowska A, Gronwald J, Wokolorczyk D, Maleszka R, Kladny J, Lubinski J. Common variants of DNA repair genes and malignant melanoma. Eur J Cancer. 2008 Jan;44(1):110-4 [Abstract]

  • Jaworowska E, Serrano-Fernandez P, Tarnowska C, Dabrowska A, Lubinski J, Kram A, Masojc B, Scott R, Lubinski J. Distinct clinical features of familial laryngeal cancer in women. Cancer Detect Prev. 2007;31(4):270-5.[Abstract]

  • Zlowocka E, Cybulski C, Gorski B, Debniak T, Slojewski M, Wokolorczyk D, Serrano-Fernandez P, Matyjasik J, van de Wetering T, Sikorski A, Scott RJ, Lubinski J. Germline mutations in the CHEK2 kinase gene are associated with an increased risk of bladder cancer. Int J Cancer. 2008; 122(3):583-6.[Abstract]

  • Matyjasik J, Cybulski C, Masojc B, Jakubowska A, Serrano-Fernandez P, Gorski B, Debniak T, Huzarski T, Byrski T, Gronwald J, Zlowocka E, Narod SA, Scott R, Lubinski J. CYP1B1 and predisposition to breast cancer in Poland. Breast Cancer Res Treat. 2007; 106(3):383-8.[Abstract]

  • Debniak T, Scott RJ, Masojc B, Serrano-Fernandez P, Huzarski T, Byrski T, Debniak B, Gorski B, Cybulski C, Medrek K, Kurzawski G, van de Wetering T, Maleszka R, Kladny J, Lubinski J. MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk. Int J Cancer. 2006; 119(11):2597-602.[Abstract]

  • Moeller M, Zettl UK, Goertsches R, Serrano-Fernandez P. Comparative genomics for the investigation of autoimmune diseases. Curr Pharm Des 2006; 12(29):3707-22.[Abstract]

  • Goertsches R, Serrano-Fernandez P, Koczan D, Moeller S, Zettl UK (2006) Transcriptomics for the monitoring of Multiple Sclerosis. Curr Pharm Des 2006; 12(29):3761-79.[Abstract]

  • Oeckinger J, Serrano-Fernandez P, Moeller S, Jagodic M, Olsson T. Definition of a 1.06 Mb region linked to neuroinflammation in humans, rats and mice. Genetics 2006; 173(3):1539-45.[Abstract]

  • Serrano-Fernandez P, Gorski B, Debniak T, Cybulski C, Byrski T, Huzarski T, Gronwald J, Jakubowska A, Oszurek O, Jan Lubinski, Polish Hereditary Cancer Consortium. Coverage of the Genetic Background of Breast Cancer in the Polish Population. Hered Cancer Clin Practise 2006; 4(1):25-7.[Full Text] (free, but requires login)

  • Lubinski J, Gorski B, Huzarski T, Byrski T, Gronwald J, Serrano-Fernandez P, Domagala W, Chosia M, Ucinski M, Grzybowska E, Lange D, Maka B, Mackiewicz A, Karczewska A, Breborowicz J, Lamperska K, Stawicka M, Gozdecka-Grodecka S, Bebenek M, Sorokin D, Wojnar A, Haus O, Sir J, Mierzwa T, Niepsuj S, Gugala K, Gozdz S, Sygut J, Kozak-Klonowska B, Musiatowicz B, Posmyk M, Kordek R, Morawiec M, Zambrano O, Wasko B, Fudali L, Skret J, Surdyka D, Urbanski K, Mitus J, Rys J, Szwiec M, Rozmiarek A, Dziuba I, Wandzel P, Wisniowski R, Szczylik C, Kozak A, Kozlowski W, Narod SA. BRCA1-positive breast cancers in young women from Poland. Breast Cancer Res Treat. 2006; 99(1):71-6.[Abstract]

  • Debniak T, Scott RJ, Huzarski T, Byrski T, Masojc B, van de Wetering T, Serrano-Fernandez P, Górski B, Cybulski C,Gronwald J, Debniak B, Maleszka R, Kladny J, Bieniek A, Nagay L, Haus O, Grzybowska E, Wandzel P, Niepsuj S, Narod SA, Lubinski J. XPD common variants and their association with melanoma and breast cancer risk. Breast Cancer Res Treat 2006; 98(2):209-15.[Abstract]

  • Jaworowska E, Masojc B, Tarnowska C, Brzosko M, Flicinski J, Serrano-Fernandez P, Matyjasik J, Amernik K, Scott RJ, Lubinski J. Association between early-onset breast and laryngeal cancers. Breast Cancer Res Treat 2006; 97(2):215-9.[Abstract].

  • Koy C, Heitner J, Woisch R, Kreutzer M, Serrano-Fernandez P, Gohlke R, Reimer T, Glocker MO. Cryodetector mass spectrometry profiling of plasma samples enables differentiation of HELLP patients from healthy donors. Proteomics 2005; 5(12):3079-87.[Abstract].

  • Möller S, Mix E, Blueggel M, Serrano-Fernandez P, Koczan D, Kotsikoris V, Kunz M, Watson M, Pahnke J, Illges H, Mikkat S, Thiesen H-J, Glocker MO, Zettl UK, Ibrahim SM. Collection of soluble variants of membrane proteins for transcriptomics and proteomics. In Silico Biology 2005; 5:0028 [Full text].

  • Serrano-Fernandez P, Ibrahim SM, Koczan D, Zettl UK, Möller S. In-silico fine-mapping: narrowing disease-associated loci by intergenomics. Bioinformatics 2005; 21(8):1737-1738. [Abstract]

  • Möller S, Koczan D, Serrano-Fernandez P, Zettl UK, Thiesen H-J, Ibrahim SM. Selecting SNPs for association studies based on population frequencies: A novel interactive tool and its application to polygenic diseases. In Silico Biology 2004; 4(4):417-27.[Full text]

  • Serrano-Fernandez P, Ibrahim SM, Thiesen H-J, Zettl UK, Gödde R, Epplen JT, Möller S. Intergenomic Consensuses of Multifactorial Inheritance Loci: the Case of Multiple Sclerosis. Genes and Immunity 2004; 5(8):615-20.[Abstract]

  • Voigt C, Ibrahim SM, Möller S, Serrano-Fernandez P. Non-linear conversion between physical and chromosomal distances. Bioinformatics 2004; 20(12):1966-7.[Abstract]

  • Fischer G, Ibrahim SM, Brockmann GA, Pahnke J, Bartocci E, Thiesen H-J, Serrano-Fernández P, Möller S. Expressionview: Visualization of Quantitative Trait Loci and Gene Expression Data in EnsEMBL. Genome Biology 2003; 4(2):R77.1-6.[Full text]

    (This article reached place 30 under the most viewed publications in 2003 after the BioMed Central index, one month after publication date)

  • Serrano-Fernandez P. GFRs and electrocommunication in interacting black ghost knife fish, Apteronotus albifrons. Journal of Comparative Physiology A 2003; 189(9):685-692.[Abstract]

  • Serrano-Fernández P, Bardasano Rubio JL. Bioelectromagnetism and behaviour in aquatic vertebrates. In: Instituto de Bioelectromagnetismo Alonso de Santa Cruz, Homenaje (ed. Bardasano Rubio JL). IBASC, Alcalá de Henares. 1999; pp. 105-124.

  • Serrano-Fernández P Fitness in Osmia rufa males. Etologia 1998; 6:69-74.[Abstract]


Congress participations

Microphone
  • XXI. Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (Thessaloniki, Greece: 2005). Oral presentation: Prospective intergenomics in MS (Authors: P. Serrano-Fernández I. Mazon-Pelaez, J. Oeckinger, M. Jagodic, T. Olsson, R. Goertsches, D. Koczan, S.M.Ibrahim, U.K. Zettl, S. Moeller).

  • 78th Congress of the German Society of Neurology DGN (Wiesbaden, Germany: 2005) Integration von Expressionsdaten und Genotypisierung fuer die Eingrenzung von Suszeptibilitaets-Genen in der Experimentellen Autoimmune Encephalomyelitis: Expressions-QTL und epistatische Effekte (Authors: P. Serrano-Fernández, S.M. Ibrahim, D. Koczan, H.J. Thiesen, R. Goertsches, U.K. Zettl, S. Moeller)

  • 53rd. American Society of Mass Spectrometry ASMS Conference on Mass Spectrometry (San Antonio, Texas: 2005) Structure determination of potential biomarker proteins derived from plasma of patients with HELLP syndrome by MALDI QIT Tof MS/MS sequencing (Authors: C. Koy, J. Heitner, M. Resch, P. Serrano-Fernández, T. Reimer, M.O. Glocker).

  • XII. International Conference Intelligent Systems for Molecular Biology (ISMB) and III. European Conference on Computational Biology (ECCB) (Glasgow, Scotland: 2004). Poster: RNA expression as quantitative trait in animal models of multiple sclerosis (Authors: S. Moeller, S. Vogler, I. Mazon-Pelaez, P. Serrano-Fernández, U.K. Zettl, H-J Thiesen, D. Koczan, S.M.Ibrahim).

  • XX. Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) (Vienna, Austria: 2004). Poster: Time-course transcriptomics of IFNB treatment in MS (Authors: P. Serrano-Fernández, Moeller S., D. Koczan, S.M.Ibrahim, H-J Thiesen, U.K. Zettl).

  • VII. International Congress of Neuroimmunology (Venice, Italy: 2004). Oral presentation: Comparative Genomics in Multiple Sclerosis (Authors: P. Serrano-Fernández, Moeller S., D. Koczan, S.M.Ibrahim, H-J Thiesen, R. Gödde, J.T. Epplen, U.K. Zettl).

  • VII. European Workshop on Fouriertransform Mass Spectrometry (Sienna, Italy: 2004). Oral presentation: Identification and Structure Characterization of Disease-associated Marker Proteins using MALDI QIT ToF MSn in Clinical Proteome Research with Patients Suffering from Rheumatoid Arthritis. (Authors: C. Koy, P. Serrano-Fernandez, S. Möller, B. Ringel, S. Mikkat, R. Martin, S. Drynda, K. Kekow, H.J. Thiesen, M.O. Glocker)

  • IV. Ostsee-Symposium Klinische Neuroimmunologie (Warnemünde, Germany: 2004). Oral presentation: Genom, Transcriptom, Proteom und MS (Authors: P. Serrano-Fernández, S. Möller, D. Koczan, S.M. Ibrahim)

  • German Conference on Bioinformatics (Garching, Germany: 2003). Oral presentation and peer-reviewed research article: Non-linear conversion between physical and chromosomal distances (Authors: C. Voigt, S.M. Ibrahim, S. Möller, P. Serrano Fernández)

  • XII. International Congress on Genes, Gene Families and Isozymes (Berlin, Germany: 2003). Pairwise gene homology vs. syntenic regions for the intergenomics of quantitative trait loci (Authors: S. Möller, P. Serrano-Fernández, S.M. Ibrahim, R. Gödde, M. Kreutzer, G. Fischer, G. Drews, J.T. Epplen, M.O. Glocker, H.J. Thiesen)[Full text]

  • IV. International Congress for Bioelectromagnetics and Progress in Science and Medicine (Alcalá de Henares, Spain: 1999) Oral presentation: Behaviour and magnetic detection in invertebrates (Authors: P. Serrano Fernández, J.J. Orgaz Fraile, J.L. Bardasano Rubio)

  • IV. Congress of the European Bioelectromagnetics Association (Zagreb, Croatia: 1998) Poster: A new method for analysis of electrocommunication in wave-type weakly electric fish (Authors: P. Serrano Fernández, J. Álvarez-Ude, J.L. Bardasano Rubio)

  • I. Spanish and IV. South American Ethology Congress (Pontevedra, Spain: 1998) Poster: Size and fitness in Osmia rufa males (Author: P. Serrano Fernández)

Grants and Awards

Diploma
  • 1994-95: EU ERASMUS grant for pregraduate studies at the University of Vienna (Austria).

  • 1997-99: Spanish FPI grant for PhD studies at the University of Alcala de Henares (Spain).

  • 1999-2000: German DAAD grant for extension of PhD studies at the University of Regensburg (Germany).

  • 2004-2006: EU MARIE CURIE grant for postdoctoral research at the University of Szczecin (Poland).

  • 2005: German QUECKENSTEDT Award for research in multiple sclerosis.

  • 2006: Award of the University of Alcala for the best PhD Thesis presented in Biology in 2003 "Premio Extraordinario de Doctorado".

  • 2006: Award of the Polish Ministry of Health for the best contribution to cancer research in Poland (together with other 10 collaborators).

Patents

Patent
  • Serrano-Fernandez P., Lubinski J. et al. Determining a Predisposition to Cancer by Identification of Genotype Combinations of Specific Variants of the Genes CYP1B1, BRCA2 AND CHEK2 PCT Patent no. WO2007148997, published 27-12-2007.

  • Lubinski J., Serrano-Fernandez P., et al. Method for determining reduced predispositon to cancer based on genetic profile - Patent application PCT/PL2009/000023

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